Zinc-Triggered Hierarchical Self-Assembly of Fibrous Helix-Loop-Helix Peptide Superstructures for Controlled Encapsulation and Release
نویسندگان
چکیده
We demonstrate a novel route for hierarchical self-assembly of sub-micron sized peptide superstructures that respond to subtle changes in Zn2+ concentration. The self-assembly process is triggered by a specific foldingdependent coordination of Zn2+ by a de novo designed non-linear helix-loop-helix peptide, resulting in a propagating fiber formation and formation of spherical superstructures. The superstructures further forms larger assemblies that can be completely disassembled upon removal of Zn2+ or degradation of the non-linear peptide. This flexible and reversible assembly strategy of the superstructures enable facile encapsulation of nanoparticles and drugs that can be released by means of different stimuli. (for Table of
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