The Biochemistry of Bacillus Lepræ
نویسندگان
چکیده
Since the cultivation, about two years ago, of the leprosy bacillus, increased attention has been directed to the study of immunity processes in infection caused by this microSrganism. Experiments which aim at the development of some method for the specific treatment of the disease have already been undertaken by Dr. Duval and his associates in this laboratory, and by Clegg in the Philippines. The present study of the chemical components of Badllus leprce has been made in order that a more analytic examination of the immunity-inducing substances present in the micro6rganism may be carried out. We believe that even though the results obtained in therapy with injections of killed bacillary suspensions prove efficacious, it will be necessary to test the relative value of extracts prepared in different ways. The present work will indicate the constituents of the organism found in such extracts as are now employed in the treatment of human leprosy. Our investigations have been confined chiefly to the quantitative determination of water, fats, lipoids, and proteins. The components of certain of these groups have been identified and estimated, and their relative toxicity has been tested. Our studies serve further to differentiate from Bacillus tuberculosis the acidfast bacillus isolated by Dr. Duval from hum~.n leprous lesions. Contrary to a preconceived notion, we have found that notwithstanding the moist appearance of fresh leprosy cultures as compared with those of the tubercle bacillus, the constant dry weight of the former is relatively higher than that of the latter. According to Hammerschlag, 1 whose findings have been corroborated by many other observers, the average water content of the tubercle
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ورودعنوان ژورنال:
- The Journal of Experimental Medicine
دوره 14 شماره
صفحات -
تاریخ انتشار 2003