SIRT1 Is a Circadian Deacetylase for Core Clock Components
نویسندگان
چکیده
The transcriptional activator CLOCK is a histone acetyltransferase that is required for the circadian expression of many genes. Asher et al. (2008) and Nakahata et al. (2008) now demonstrate that the NAD(+)-dependent enzyme SIRT1 functions as a histone deacetylase that counteracts the activity of CLOCK. These results broaden our understanding of the impact of cellular metabolism on the circadian system.
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ورودعنوان ژورنال:
- Cell
دوره 134 شماره
صفحات -
تاریخ انتشار 2008