Table 3: Validation Parameter of Ultra Performance Liquid Chromatographic Method for Topotecan

Indian Journal of Pharmaceutical Sciences 497 July August 2010 analysis of topotecan hydrochloride in bulk and its injection dosage form. It does not suffer from any interference due to common excipients present in the pharmaceutical preparation and can be conveniently adopted for quality control analysis. We have developed a sensitive UPLC method for the determination of topotecan using small volumes of sample (2 μl). The developed method proved superior and economic because of its greater sensitivity and relatively shorter (4 min) run time. It is an important tool for speedy future analysis of topotecan hydrochloride in bulk and its injection dosage form.