Platelet function defects related to cardiopulmonary bypass.
نویسنده
چکیده
منابع مشابه
Platelet composition and function in patients undergoing cardiopulmonary bypass for heart surgery.
BACKGROUND Previous studies showed severe biochemical and functional damage to platelets in patients undergoing cardiopulmonary bypass for cardiac surgery, and suggested that this derived from the proteolytic action of plasmin on the platelet surface. METHODS A double-blind study was carried out to compare platelet function and composition in patients randomized to receive the protease inhibi...
متن کاملPrevention of Acquired Transient Defect in Platelet Plug Formation
Cardiopulmonary bypass in baboons produced transient severe platelet dysfunction (bleeding times prolonged to 27.8 ± 1 .4 mm compared with 3.9 ± 0.7 baseline) that was associated with a parallel release of platelet a-granule proteins into plasma (platelet factor 4 and $-thromboglobulin levels of 28.8 ± 9.3 and 20.0 ± 1 .8 ng/ml. respectively) and their clearance into urine with a reciprocal dep...
متن کاملA rapid platelet function assay used to regulate platelet transfusion prophylaxis following cardiopulmonary bypass surgery.
Subsequent to cardiac surgery with cardiopulmonary bypass (CPB), patients are at risk of postoperative bleeding caused by acquired defects associated with the procedure. As such, many patients receive prophylactic blood product transfusion. The effectiveness of measuring platelet function using a near-patient platelet function analyzer for the purpose of regulating platelet transfusion and pote...
متن کاملEcomment. Postoperative Bleeding without Re-exploration May Increase Opera- Tive Mortality Ecomment. Re: Re-exploration for Bleeding or Tamponade after Cardiac Operation
torial [2, 4]. Perioperative bleeding is related to surgical damage to blood vessels and defects in haemostatic mechanisms. The majority of haemostatic defects are related to the exposure of blood elements to the cardiopulmonary bypass circuit [2, 4]. Excessive administration of protamine is a proposed mechanism of bleeding [2]. It has been proved that CBP causes a reduction in the levels of co...
متن کاملeComment. Re: Re-exploration for bleeding or tamponade after cardiac operation.
torial [2, 4]. Perioperative bleeding is related to surgical damage to blood vessels and defects in haemostatic mechanisms. The majority of haemostatic defects are related to the exposure of blood elements to the cardiopulmonary bypass circuit [2, 4]. Excessive administration of protamine is a proposed mechanism of bleeding [2]. It has been proved that CBP causes a reduction in the levels of co...
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ورودعنوان ژورنال:
- Blood
دوره 82 7 شماره
صفحات -
تاریخ انتشار 1993