Smooth muscle - specific expression of SV 40 large T antigen induces smooth muscle proliferation that results in adaptive arterial remodeling
نویسندگان
چکیده
This work has been supported in part by a Merit Review from the Veterans Administration (Dr. March) and grant R01-HL57411 from the NIH/US Public Health Service (Dr. March), as well as the Cryptic Masons Medical Research Foundation (Dr. Sindermann) and an “Innovative Medical Research” grant and “IZKF” grant (project A10) of the University of Münster (Dr. Sindermann). Part of the work was awarded by the North American Vascular Biology Organization (NAVBO) and by the German Heart Foundation (Heinz-Meise Award).
منابع مشابه
Diagnostic Value of Proliferatin Index Including MIB1 and Argyrophilic Nucleolar Organizer Regions Proteins in Uterine Smooth Muscle Tumors
Background and Objectives: Uterine smooth muscle tumors are the most common human neoplasm .They are divided clinically as benign and malignant but there is another group of lesions which is difficult to place in these two categories ,so-called smooth muscle tumors of uncertain malignant potential (STUMP) and differentiation of these tumors on the basis of H&E staining is impossible . Th...
متن کاملTGF-ß1 Latency Associated Peptide Promotes Remodeling of Healing Cutaneous Wounds in the Rat
Background: The process of wound healing involves integrated events including inflammation, granulation tissue formation, matrix deposition and remodeling. Growth factors play a key role in the process. Among them transforming growth factor-ß1 (TGF-ß1) is known to accelerate tissue repair by promoting the synthesis and deposition of extracellular matrix proteins. However, persistence or overact...
متن کاملThe role of autophagy in advanced glycation end product-induced proliferation and migration in rat vascular smooth muscle cells
Objective(s): To investigate the role of autophagy in advanced glycation end products (AGEs)-induced proliferation and migration in rat vascular smooth muscle cells (VSMCs).Materials and Methods: After culture, VSMCs were treated with 0, 1, 10, and 100 μg/ml concentrations of AGEs. Autophagy specific protein light chain 3 (LC3)-I/II was determined by western blotting, autophagosomes were observ...
متن کاملConditional expression of a dominant-negative c-Myb in vascular smooth muscle cells inhibits arterial remodeling after injury.
Inhibiting activity of the c-Myb transcription factor attenuates G1 to S phase cell cycle transitions in vascular smooth muscle cells (SMCs) in vitro. To determine the effects of arterial SMC-specific expression of a dominant-negative c-Myb molecule (Myb-Engrailed) on vascular remodeling in vivo, we performed carotid artery wire-denudation in 2 independent lines of binary transgenic mice with S...
متن کاملUrsolic acid induces myoglobin expression and skeletal muscle remodeling in mice
Introduction: Ursolic Acid (UA) is a lipophilic triterpenoid compound, found in large amounts in apple peel. Anabolic effects of UA on the skeletal muscle and the role of this tissue as a key regulator of systematic aging aroused this question in mind whether UA might amend skeletal muscle performances such as myoglobin expression and also whether it switches skeletal muscle fibers from glyc...
متن کامل