NPP-16/Nup50 Function and CDK-1 Inactivation are Associated with Anoxia- Induced Prophase Arrest in C. elegans
نویسندگان
چکیده
Induced Prophase Arrest in C. elegans Vinita A. Hajeri, Brent A. Little, Mary L. Ladage, Pamela A. Padilla* Department of Biological Sciences, University of North Texas, Denton TX 76203 Running Title: Prophase Arrest in C. elegans *Corresponding Author: P.A. Padilla, Department of Biological Sciences, University of North Texas, Denton TX 76203, Phone: (904) 565-3614, fax (940) 565-3821 [email protected]
منابع مشابه
NPP-16/Nup50 Function and CDK-1 Inactivation Are Associated with Anoxia-induced Prophase Arrest in Caenorhabditis elegans
Oxygen, an essential nutrient, is sensed by a multiple of cellular pathways that facilitate the responses to and survival of oxygen deprivation. The Caenorhabditis elegans embryo exposed to severe oxygen deprivation (anoxia) enters a state of suspended animation in which cell cycle progression reversibly arrests at specific stages. The mechanisms regulating interphase, prophase, or metaphase ar...
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Oocytes are released from meiotic prophase I arrest through a process termed oocyte maturation. We present here a genetic characterization of oocyte maturation, using C. elegans as a model system. We show that two TIS11 zinc finger-containing proteins, OMA-1 and OMA-2, express specifically in maturing oocytes and function redundantly in oocyte maturation. Oocytes in oma-1;oma-2 mutants initiate...
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Some metazoans have evolved the capacity to survive severe oxygen deprivation. The nematode, Caenorhabditis elegans, exposed to anoxia (0 kPa, 0% O(2)) enters into a recoverable state of suspended animation during all stages of the life cycle. That is, all microscopically observable movement ceases including cell division, developmental progression, feeding, and motility. To understand suspende...
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The orderly progression through the cell division cycle is of paramount importance to all organisms, as improper progression through the cycle could result in defects with grave consequences. Previously, our lab has shown that model eukaryotes such as Saccharomyces cerevisiae, Caenorhabditis elegans, and Danio rerio all retain high viability after prolonged arrest in a state of anoxia-induced s...
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