Neurobiology of Disease LRRK2 Inhibition Attenuates Microglial Inflammatory Responses
نویسندگان
چکیده
Mark S. Moehle,1,4,5* Philip J. Webber,1,4,5* Tonia Tse,1,4 Nour Sukar,1,4 David G. Standaert,1,4 Tara M. DeSilva,2,4 Rita M. Cowell,3,4 and Andrew B. West1,4 Departments of 1Neurology, 2Physical Medicine and Rehabilitation, and 3Psychiatry and Behavioral Neurobiology, 4Center for Neurodegeneration and Experimental Therapeutics, and 5Neuroscience Graduate Program, University of Alabama at Birmingham, Birmingham, Alabama 35294
منابع مشابه
LRRK2 G2019S mutation attenuates microglial motility by inhibiting focal adhesion kinase
In response to brain injury, microglia rapidly extend processes that isolate lesion sites and protect the brain from further injury. Here we report that microglia carrying a pathogenic mutation in the Parkinson's disease (PD)-associated gene, G2019S-LRRK2 (GS-Tg microglia), show retarded ADP-induced motility and delayed isolation of injury, compared with non-Tg microglia. Conversely, LRRK2 knoc...
متن کاملAge-related pathology after adenoviral overexpression of the leucine-rich repeat kinase 2 in the mouse striatum
Mutations in leucine-rich repeat kinase 2 (LRRK2) age-dependently cause Parkinson's disease and are associated with several inflammatory diseases. So far, the potential role of LRRK2 expression in glial cells as mediators of neuroinflammation and the influence of aging have not been investigated in viral vector-based LRRK2 animal models. In this study, we compared the effect of striatal injecti...
متن کاملP185: Survey Effect of Histamine on Microglia in Neurodegenerative Diseases
Neurodegenerative diseases contain Multiple Sclerosis (MS), Alzheimer’s disease (AD) and Parkinson’s disease (PD), are characterized by neuronal death and neuronal degeneration in specific regions of the central nervous system (CNS). Microglia are the basic immune brain cells and play a role in homeostasis after inflammation challenge. Microglia involves in Neurodegenerative disease...
متن کاملP 106: Effects of Dimethyl Sulfoxide on NLRP3 Inflammasome and Alzheimer\'s Disease
Alzheimer's disease (AD), the most ordinary form of dementia and extracellular accumulation of Amyloid-β (Aβ) in senile plaques, is an important and a main event in the pathogenesis of AD. Deposition of Aβ Peptide initiates a spectrum of cellular responses that are interposed by the resident neuroimmune cells of the brain, the microglia. Recently, a novel inflammasome signaling&n...
متن کاملNeurobiology of Disease Regulation of Microglial Proliferation during Chronic Neurodegeneration
An important component of chronic neurodegenerative diseases is the generation of an innate inflammatory response within the CNS. Microglial and astroglial cells play a key role in the development and maintenance of this inflammatory response, showing enhanced proliferation and activation. We studied the time course and regulation of microglial proliferation, using a mouse model of prion diseas...
متن کامل