Evaluation of the Diuretic Effects of Crocin (active Constituent of Saffron) in Rats
ثبت نشده
چکیده
Aim of this study is to confirm and investigate the diuretic effect of crocine which is the pharmacologically active component of Crocus sativus L. (saffron) and to study the possible mechanism of action in relation to urinary nitrite. Twenty four rats were divided into 3 groups; control, hydrochlorothiazide and crocine treated groups. Assay of the diuretic activity of crocine was performed by determination of urine volume, urine sodium and chloride. Creatinine clearance or urinary nitrites were measured. Hydrochlorothiazide is chosen as a standard diuretic because it has moderate potency and an intermediate duration of action. oral administration of Both Hydrochlorothiazide and Crocin produced a significant increase of the 5 hours urine volume, urine sodium and chloride. Oral administration of crocin produced a significant increase of creatinine clearance and urinary nitrites. Crocine has a diuretic effect in rats. It induces its diuretic effect partially through simulation of Nitric oxide..
منابع مشابه
Evaluation of the Diuretic Effects of Crocin (active Constituent of Saffron) in Rats
Aim of this study is to confirm and investigate the diuretic effect of crocine which is the pharmacologically active component of Crocus sativus L. (saffron) and to study the possible mechanism of action in relation to urinary nitrite. Twenty four rats were divided into 3 groups; control, hydrochlorothiazide and crocine treated groups. Assay of the diuretic activity of crocine was performed by ...
متن کاملAnti-obesity and Anorectic Effects of Saffron and its Constituent Crocin in Obese Wistar Rat
Background: Obesity is pandemic worldwide and a strong risk factor for cardio-metabolic disorders. The few approved anti-obesity drugs have poor efficacy and safety profile. Thus, there is an urgent need for new anti-obesity agents. According to the traditional medicine and a clinical trial, saffron may have anorexigenic and anti-obesity effects which need further investigation. Objectives: Ev...
متن کاملEffect of crocin, an active saffron constituent, on ethanol toxicity in the rat: histopathological and biochemical studies
Objective(s): The drinking of ethanol causes the wide range of clinical illness and morphological changes including hepatotoxicity and nephrotoxicity. In the current study, the protective properties of crocin versus oxidative stress, apoptosis and inflammation induced by ethanol were assessed. Materials and Methods: The male Wistar rats ...
متن کاملAnti-hyperglycemic Effects of Saffron and its Active Constituents, Crocin and Safranal, in Alloxan-Induced Diabetic Rats
Background: Saffron is the dried stigmata of the flowers of saffron (Crocus sativus L., Iridaceae). Saffron and its major active constituents, crocin (crocetin glycoside), crocetin and safranal, have a variety of pharmacological effects including high antioxidant properties and crocetin has insulin sensitizing effect possibly due to its antioxidant activity. Oral crocin is not absorbed and is h...
متن کاملEffects of Saffron and its Active Constituents, Crocin and Safranal, on Prevention of Indomethacin Induced Gastric Ulcers in Diabetic and Nondiabetic Rats
Background: Saffron is the dried stigmata of the flowers of saffron (Crocus sativus L., Iridaceae). Saffron is well known for the treatment of gastric disorders in traditional medicine. Objectives: In the search for new potential antiulcer agents, the effects of the ethanol extract of saffron and its active constituents crocin and safranal as compared with omeprazole against gastric ulcer i...
متن کامل