Bortezomib and bilateral herpes zoster.
نویسندگان
چکیده
Bortezomib is a proteasome inhibitor that has proven to be a very effective treatment for multiple myeloma. There is considerable debate about the potential for reactivation of the varicella zoster virus (VZV) in patients with multiple myeloma during treatment with bortezomib. This report describes the case of a 70-year-old patient with multiple myeloma that developed bilateral herpes zoster shortly after being treated with bortezomib. Furthermore, it emphasizes the importance of using an antiviral prophylaxis with acyclovir in these patients treated with bortezomib.
منابع مشابه
Herpes zoster duplex bilateralis in bortezomib-based chemotherapy
which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. A 68-year-old female patient with IgG kappa-type multiple myeloma was treated with a bortezomib-based regimen. She had bilateral back pain 1 month after the chemotherapy. Because she had no skin lesions, we initially suspected, but did not find, a bone fract...
متن کاملConcerns in assessing risk factors for herpes zoster infection in multiple myeloma patients
which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Concerns in assessing risk factors for herpes zoster infection in multiple myeloma patients TO THE EDITOR: Recent developments of new agents such as bortezomib and high-dose chemotherapy followed by stem cell transplantation for multiple myeloma have improve...
متن کاملLow-dose acyclovir is effective for prevention of herpes zoster in myeloma patients treated with bortezomib: a report from the Korean Multiple Myeloma Working Party (KMMWP) Retrospective Study.
OBJECTIVE Acyclovir prophylaxis has been considered as mandatory for patients receiving bortezomib because herpes zoster is a common adverse event associated with the use of bortezomib. Although the minimal effective dose of acyclovir for prophylaxis has not yet established, the efficacy of low-dose acyclovir prophylaxis, 400 mg once daily, has been suggested. METHODS We retrospectively revie...
متن کاملIncidence, risk factors and prevention of herpes zoster: review article
Herpes zoster (Shingles; Zona) is an acute infectious skin disease that is caused by the reactivation of varicella zoster virus (VZV). After the initial infection (chickenpox) or vaccination, the virus remains inactive or latent in the dorsal root ganglia (DRG); when decreasing cell mediated immunity (CMI) occurs, the virus is reactivated from a latent phase to a lytic phase and frequently repl...
متن کاملBilateral Symmetrical Herpes Zoster in an Immunocompetent 15-Year-Old Adolescent Boy
Herpes zoster is uncommon in immunocompetent children. The bilateral symmetrical occurrence of herpes zoster lesions is extremely rare. We report a 15-year-old immunocompetent Chinese adolescent boy who developed bilateral symmetrical herpes zoster lesions. To our knowledge, the occurrence of bilateral symmetrical herpes zoster lesions in an immunocompetent individual has not been reported in t...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Acta dermatovenerologica Alpina, Pannonica, et Adriatica
دوره 21 1 شماره
صفحات -
تاریخ انتشار 2012