Calix[4]pyrroles: New Solid-Phase HPLC Supports for the Separation of Anions**
نویسندگان
چکیده
The preparation of two distinct calix[4]pyrrole-modified silica gels is reported. These systems, designed to investigate the binding characteristics of calix[4]pyrroles with anionic and neutral substrates, also provide a new solid support for the HPLC separation of nucleotides, oligonucleotides, N-protected amino acids and perfluorinated biphenyls. Binding affinities for the interaction of anions with calix[4]pyrrole amide derivatives are also reported; these were determined from 1H NMR spectroscopic analyses carried out in CD2Cl2.
منابع مشابه
Results and Discussions
Calix (4) pyrroles are macromolecules structurally related to porphyrins, they exhibit exceptional chemical and physical properties that have suggested a vast number of potential applications in host-guest chemistry. In recent years, calix (4) pyrroles have attracted a lot of attention because of their properties as binders of anions, transition metals, and neutral substrates and their new appl...
متن کاملThe Combination Process for Preparative Separation and Purification of Paclitaxel and 10-Deacetylbaccatin III Using Diaion® Hp-20 Followed by Hydrophilic Interaction Based Solid Phase Extraction
There is no other naturally occurring defense agent against cancer that has a stronger effectthan paclitaxel, commonly known under the brand name of Taxol®. The major drawback for themore widespread use of paclitaxel and its precious precursor, 10-deacetylbaccatin III (10-DABIII), is that they require large-scale extraction from different parts of yew trees (Taxus species),cell cultures, taxane...
متن کاملThe Combination Process for Preparative Separation and Purification of Paclitaxel and 10-Deacetylbaccatin III Using Diaion® Hp-20 Followed by Hydrophilic Interaction Based Solid Phase Extraction
There is no other naturally occurring defense agent against cancer that has a stronger effectthan paclitaxel, commonly known under the brand name of Taxol®. The major drawback for themore widespread use of paclitaxel and its precious precursor, 10-deacetylbaccatin III (10-DABIII), is that they require large-scale extraction from different parts of yew trees (Taxus species),cell cultures, taxane...
متن کاملCreated Using the Rsc Communication Template (ver. 2.1) - See Www.rsc.org/electronicfiles for Details
Calix[4]pyrroles such as meso-octamethylcalix[4]pyrrole 1 have been extensively studied as anion and ion-pair receptors over recent years. Subsequently ‘strapped’ calix[4]pyrroles, pioneered by Lee and Sessler, have been synthesised that contain a single linker between distal meso-positions. These compounds have increased 15 affinity for anions relative to the parent macrocycle. Recently there ...
متن کاملDetermination of Some Polycyclic Aromatic Hydrocarbons in the Caspian Seawater by HPLC Following Preconcentration with Solid-Phase Extraction
A solid-phase extraction (SPE) method for sample clean-up and preconcentration followed by reversed-phase high-performance liquid chromatography (RP-HPLC) with uv detection is reported for determination of polycyclic aromatic hydrocarbons (PAHs) in the caspian seawater. A good resolution was obtained using acetonitrile:water (40:60) as mobile-phase for separation of these compounds. The eff...
متن کامل