Ksp-cadherin gene promoter. II. Kidney-specific activity in transgenic mice.

Regulation of kidney-specific Ksp-cadherin gene promoter by hepatocyte nuclear factor-1beta.

Kidney-specific cadherin (Ksp-cadherin) is a tissue-specific member of the cadherin family that is expressed exclusively in the kidney and developing genitourinary tract. Recent studies have shown that the proximal 250 bp of the Ksp-cadherin gene promoter are sufficient to direct tissue-specific gene expression in vivo and in vitro. The proximal 120 bp of the promoter are evolutionarily conserv...

Ksp-cadherin gene promoter. I. Characterization and renal epithelial cell-specific activity.

Kidney-specific cadherin (Ksp-cadherin, cadherin 16) is a novel, kidney-specific member of the cadherin superfamily that is expressed exclusively in the basolateral membrane of renal tubular epithelial cells. To characterize the Ksp-cadherin gene promoter, a λ bacteriophage clone containing 3.7 kb of the proximal 5' flanking region of the mouse Ksp-cadherin gene was isolated. The transcription ...

Regulation of the Kidney-Specific Ksp-Cadherin Gene Promoter by Hepatocyte Nuclear Factor-1 (HNF-1 )

E-cadherin Promoter Methylation Comparison and Correlation with the Pathological Features of the Squamous Cell Carcinoma of Esophagus in the High Risk Region

E-cadherin is among tumor suppressor genes which mostly subjects to the down-regulation in squamous cell carcinoma of esophagus (SCCE). The gene is tightly associated with the tumor invasion and metastasis in multiple human cancers, especially SCCE. CpG islands’ methylation in the promoter region of E-cadherin is among the mechanisms that have been suggested for the E-cadherin silencing, howeve...

Regulation of kidney-specific Ksp-cadherin gene promoter by hepatocyte nuclear factor-1

YUN BAI,1 MARCO PONTOGLIO,2 THOMAS HIESBERGER,1 ANGUS M. SINCLAIR,1 AND PETER IGARASHI1 1Division of Nephrology, Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390; and 2Unité d’Expression Génétique et Maladies, Centre National de la Recherche Scientifique URA 1644, Département de Biologie du Développement, Institut Pasteur, 75724 Par...