Cortico-Striatal GABAergic and Glutamatergic Dysregulations in Subjects at Ultra-High Risk for Psychosis Investigated with Proton Magnetic Resonance Spectroscopy Running title GABA and Glx in Ultra-High Risk for Psychosis
نویسندگان
چکیده
Laboratory of Experimental Psychiatry, Instituto Nacional de Neurología y Neurocirugía, Mexico City, Mexico; Neuropsychiatry Department, Instituto Nacional de Neurología y Neurocirugía, Mexico City, Mexico; Department of Radiology, Weill Cornell Medical College, New York, NY, United States of America; Department of Education, Instituto Nacional de Neurología y Neurocirugía, Mexico City, Mexico; Early Psychosis Intervention Department, Hospital Fray Bernardino Alvarez, Mexico City, Mexico; Palliative Care Unit, Instituto Nacional de Cancerología, Mexico City, Mexico; Laboratory of Neuropsychology, Instituto Nacional de Neurología y Neurocirugía, Mexico City, Mexico; MR Advanced Applications, GE Healthcare, Mexico City, Mexico; Multimodal Neuroimaging Schizophrenia Group, Research Imaging Centre, and Geriatric Mental Health Program at Centre for Addiction and Mental Health and Department of Psychiatry, University of Toronto, Canada
منابع مشابه
Cortico-Striatal GABAergic and Glutamatergic Dysregulations in Subjects at Ultra-High Risk for Psychosis Investigated with Proton Magnetic Resonance Spectroscopy
BACKGROUND Dysregulations of the major inhibitory and excitatory amino neurotransmitter systems of γ-aminobutyric acid and glutamate, respectively, have been described in patients with schizophrenia. However, it is unclear whether these abnormalities are present in subjects at ultra-high risk for psychosis. METHODS Twenty-three antipsychotic naïve subjects at ultra-high risk and 24 healthy co...
متن کاملReduced γ-Aminobutyric Acid and Glutamate+Glutamine Levels in Drug-Naïve Patients with First-Episode Schizophrenia but Not in Those at Ultrahigh Risk
Altered γ-aminobutyric acid (GABA), glutamate (Glu) levels, and an imbalance between GABAergic and glutamatergic neurotransmissions have been involved in the pathophysiology of schizophrenia. However, it remains unclear how these abnormalities impact the onset and course of psychosis. In the present study, 21 drug-naïve subjects at ultrahigh risk for psychosis (UHR), 16 drug-naïve patients with...
متن کاملCortical GABA in Subjects at Ultra-High Risk of Psychosis: Relationship to Negative Prodromal Symptoms
Background Whilst robust preclinical and postmortem evidence suggests that altered GABAergic function is central to the development of psychosis, little is known about whether it is altered in subjects at ultra-high risk of psychosis, or its relationship to prodromal symptoms. Methods Twenty-one antipsychotic naïve ultra-high risk individuals and 20 healthy volunteers underwent proton magneti...
متن کاملGlutamate dysfunction in people with prodromal symptoms of psychosis: relationship to gray matter volume.
BACKGROUND The glutamate model of schizophrenia proposes that altered glutamatergic neurotransmission is fundamental to the development of the disorder. In addition, its potential to mediate neurotoxicity raises the possibility that glutamate dysfunction could underlie neuroanatomic changes in schizophrenia. Here we determine whether changes in brain glutamate are present in subjects at ultra h...
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Hippocampal pathology has been shown to be central to the pathophysiology of schizophrenia and a putative risk marker for developing psychosis. We applied both (1)H MRS (proton magnetic resonance spectroscopy) at 3Tesla and voxel-based morphometry (VBM) of high-resolution brain structural images in order to study the association of the metabolites glutamate (Glu) and N-acetyl-aspartate (NAA) in...
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