Fatty Acid Binding Protein-1 (fabp-1) of Echinococcus Granulosus- a Promising Vaccine Candidate- an in Silico Analysis
نویسندگان
چکیده
Varun Chauhan1, Gurjeet Kaur2, Naveen2, Kapil Goyal2, Rakesh Sehgal2 1 Department of Virology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, Punjab (India)160012. 2 Sophisticated Analytical Instruments Laboratories, Thapar University, Patiala, Punjab (India)147004. 3 Department of Medical Parasitology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, Punjab (India)-160012.
منابع مشابه
Binding properties of Echinococcus granulosus fatty acid binding protein.
EgFABP1 is a developmentally regulated intracellular fatty acid binding protein characterized in the larval stage of parasitic platyhelminth Echinococcus granulosus. It is structurally related to the heart group of fatty acid binding proteins (H-FABPs). Binding properties and ligand affinity of recombinant EgFABP1 were determined by fluorescence spectroscopy using cis- and trans-parinaric acid....
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We describe the 1.6 A crystal structure of the fatty-acid-binding protein EgFABP1 from the parasitic platyhelminth Echinococcus granulosus. E. granulosus causes hydatid disease, which is a major zoonosis. EgFABP1 has been implicated in the acquisition, storage, and transport of lipids, and may be important to the organism since it is incapable of synthesising most of its lipids de novo. Moreove...
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Fatty acid-binding proteins (FABPs) are candidate molecules for vaccines against several parasitic platyhelminths. A FABP from the cestode Echinococcus granulosus (EgDf1) was expressed in Salmonella vaccine strains as a C-terminal fusion to fragment C of tetanus toxin (TetC) by using expression vector pTECH. The fusion protein was equally expressed in several attenuated vaccine strains derived ...
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