Enantioselective chlorination and fluorination of beta-keto phosphonates catalyzed by chiral Lewis acids.

نویسندگان

  • Luca Bernardi
  • Karl Anker Jørgensen
چکیده

The direct chiral Lewis acidic enantioselective chlorination and fluorination of beta-keto phosphonates is presented; the chlorination proceeds in high yields and with up to 94% ee using NCS as the chloro source, while the fluorination with (PhSO2)2NF (NFSI) gives the optically active alpha-fluoro-beta-keto phosphonates in moderate to good yields and with up to 91% ee.

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عنوان ژورنال:
  • Chemical communications

دوره 10  شماره 

صفحات  -

تاریخ انتشار 2005