Lepromin and tuberculin tests in Venezuelan leprosy foci; induction of lepromin reactivity by BCG vaccination.
نویسندگان
چکیده
The work reported in this paper was carried out by the Fourth Antileprosy Service of the Leprosy Division of the Ministry of Health of Venezuela. It was planned for the purpose of studying the lepromin and tuberculin reactions before and after the administration of BCG in a relatively large group of persons living in leprosy foci of rural areas. Statistics regarding the induction of the lepromin reaction by BCG would be valuable as a criterion for the extension of vacCination to all foci in the country. MATERIALS AND METHODS
منابع مشابه
The effect of BCG in lepromatous cases of leprosy.
As we have recently reported (2), in cases of lepromatous leprosy, which almost by defiI1ition are lepromin negative, the administration of BCG causes in some cases an increase in the reactivity to lepromin as well as the usual tuberculin conversions. The following are the data there reported, now slightly revised: One hundred and four lepromatous cases, negative to both tuberculin and lepromin...
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While investigations were in progress elsewhere in Venezuela on the modifications of the reactions to tuberculin and lepromin after BeG vaccination in groups of humans in leprosy-endemic foci (2). parallel experiments were made with hamsters and guinea-pigs at the Cabo Blanco Leprosarium. The results are reported here. The problem of lepromin sensitization in animals has attracted the attention...
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A great many investigations have been carried out in attempts to elucidate. first, the reactivity of leprosy patients to tubercuJin , a subject well reviewed by Wade (7). and then of late years the relationship between the lepromin and tuberculin reactions. The concept that persons immune to tuberculosis may also be immune to leprosy has recently received support from some workers. Attention ha...
متن کاملResponse of Mycobacterium habana vaccine in patients with lepromatous leprosy and their household contacts. A pilot clinical study.
Single dose vaccination was carried out with Mycobacterium habana vaccine, 31 lepromatous leprosy cases receiving 1.5 mg (1.5 mg = 6.27 x 10(8) bacilli) and 36 household contacts randomly receiving 1.5, 2.0, 2.5 mg vaccine intradermally. Duration of study was 18 weeks. Vaccination induced lepromin conversion in 100% of lepromatous leprosy cases and lepromin negative household contacts and augme...
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ورودعنوان ژورنال:
- International journal of Leprosy
دوره 22 3 شماره
صفحات -
تاریخ انتشار 1954