Synthesis and Study of Analgesic, Anti-inflammatory Activities of 3-methyl-5- Pyrazolone Derivatives

Considerable amount of research has been carried out in the field of pyrazolone derivatives due to their diverse biological, pharmacological and chemical properties. The need was felt to synthesize certain 3-methyl-5-pyrazolone derivatives with potent analgesic and anti-inflammatory activity and with lesser side effects as it had been proved of late that the beneficial effects of pyrazolones outweigh its adverse effects. The present work involved the synthesis of some aryl 3-methyl-5-pyrazolone derivatives by Knorr-Pyrazolone condensation followed by subsequent one step Knovenagel-Michael condensation and the evaluation of the analgesic and anti-inflammatory activities of the synthesized compounds using Acetic acid writhing method in Swiss Albino mice and Carageenan induced rat paw edema in Wistar rat respectively.