Optical coherence tomographic angiography of choroidal neovascularization associated with central serous chorioretinopathy.

Optical Coherence Tomographic Angiography of Choroidal Neovascularization Associated With Central Serous Chorioretinopathy Choroidal neovascularization (CNV) can complicate chronic central serous chorioretinopathy (CSC) and may be difficult to diagnose because CSC itself can be associated with pigment epithelial detachment, subretinal fluid, and ill-defined patterns of hyperfluorescence on fluorescein angiography (FA).1,2 Structural optical coherence tomographic (OCT) techniques such as en face OCT have been used to identify CNV but the vascular contrast is low, limiting image detail.3 This case report describes OCT angiography of CNV in chronic CSC. Methods | Macular angiograms (3 × 3 mm) were obtained using spectral-domain OCT (70 kHz; RTVue XR; Optovue). The split-spectrum amplitude-decorrelation angiography algorithm was used to distinguish blood flow from static tissue, and angiograms were segmented into 3 vascular slabs: inner retinal, outer retinal, and choriocapillaris as described in detail previously.4 Choroidal neovascularization was defined as flow in the outer retinal slab between the Bruch membrane and outer plexiform layer. Choriocapillaris angiograms were based on flow signal within 10 μm below the Bruch membrane. The parafoveal retinal vessel density and CNV area were calculated as previously described.4,5 The Oregon Health and Science University Institutional Review