Relation of urinary total hydroxyproline: creatinine ratio

et al., 1967; Zorab et al., 1970). Allison, Walker, and Smith (1966) showed that the ratio of total hydroxyproline to creatinine in a 24-hour collection of urine gives more consistent results than measurement of hydroxyproline alone, an observation which has been extended to random samples of urine collected during waking hours (Howells, Wharton, and McCance, 1967; Younoszai et al., 1969). Wharton et al. (1972) have defined the normal range for total hydroxyproline: creatinine ratios in random urine samples collected from British children, and they also showed a similarity between the excretion pattern according to age, and the pattern of growth velocity defined by Tanner, Whitehouse, and Takaishi (1966). They suggested a number of possible clinical uses for the hydroxyproline: creatinine estimation, and in particular that it might be a useful adjunct to anthropometry and radiology in assessment of growth. The estimation of the total hydroxyproline :creatinine ratio has been found to be valuable in the management of children with growth hormone deficiency (Wharton