The Distinctive Mutational Spectra of Polyomavirus-Negative Merkel Cell Carcinoma Running Title: Mutational Spectra of Polyomavirus-Negative Merkel Cell Carcinoma
نویسندگان
چکیده
Affiliations 1. Michigan Center for Translational Pathology, University of Michigan Medical School 2. Department of Pathology, University of Michigan Medical School 3. Department of Dermatology, University of Michigan Medical School 4. Department of Biomedical Science, Bharathidasan University, Tiruchirappalli, India 5. Department of Urology, Henry Ford Health System, Detroit, MI 6. Howard Hughes Medical Institute, University of Michigan Medical School, Ann Arbor, MI 48109,USA 7. Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA 8. Department of Urology, University of Michigan Medical School, Ann Arbor, MI 48109 USA 9. Department of Cell and Developmental Biology, University of Michigan Medical Center, Ann Arbor, USA
منابع مشابه
The Distinctive Mutational Spectra of Polyomavirus-Negative Merkel Cell Carcinoma.
Merkel cell carcinoma (MCC) is a rare but highly aggressive cutaneous neuroendocrine tumor. Merkel cell polyomavirus (MCPyV) may contribute to tumorigenesis in a subset of tumors via inhibition of tumor suppressors such as retinoblastoma (RB1) by mutated viral T antigens, but the molecular pathogenesis of MCPyV-negative MCC is largely unexplored. Through our MI-ONCOSEQ precision oncology study,...
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Merkel cell carcinoma (MCC) is a rare but highly aggressive cutaneous neuroendocrine carcinoma, associated with the Merkel cell polyomavirus (MCPyV) in 80% of cases. To define the genetic basis of MCCs, we performed exome sequencing of 49 MCCs. We show that MCPyV-negative MCCs have a high mutation burden (median of 1121 somatic single nucleotide variants (SSNVs) per-exome with frequent mutation...
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Merkel cell carcinomas (MCCs) are uncommon, highly malignant skin tumors that develop in sun-exposed areas of the skin. Most of the MCCs are CK 20-positive and CK 7-negative such as our case. About 80% of Merkel cell carcinoma is associated with Merkel cell polyomavirus.
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BACKGROUND Merkel cell carcinoma is a rare malignancy of the skin. Integration of Merkel cell polyomavirus (MCPyV) DNA to the tumor genome is frequent in these cancers. The clinical consequences of MCPyV infection are unknown. METHODS We analyzed formalin-fixed paraffin-embedded Merkel cell carcinoma tissue samples from 114 of 207 patients diagnosed with Merkel cell carcinoma in Finland from ...
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