Biocellular Regenerative Medicine

Over the past decade, great strides have been made in the understanding and potential of targeted cell-based therapies. Starting decades ago, use of an irritant solution to stimulate inflammatory reactions has been replaced in the past few years with transition to injecting various platelet-rich plasma (PRP) concentrates for supporting an effective inflammatory reaction at damaged or degenerative sites. Use of the contained growth factors and signal proteins became recognized as offering a significant improvement in tissue healing responses but seemed limited by incomplete repair while requiring a series (often 4–6) to achieve long-term clinical improvement. Current evolution of combining these trophic growth factors and signal proteins with concentrated undifferentiated cellular/stromal populations seemed like a logical and effective modality, moving into the forefront since 2000. Aesthetic and reconstructive applications led the way, because constant challenges of injury, loss of circulatory capabilities, degenerative, repair, and so forth demanded an optimal approach to regenerative needs. In-depth examination of how the body maintains itself revealed that undesignated cells were integrally important to replacing aging cells (such as