Electrochemical studies for the determination of quetiapine fumarate and olanzapine antipsychotic drugs.

PURPOSE Cyclic voltammetry and differential pulse voltammetry were used to explore the diffusion behavior of two antipsychotic drugs at a glassy carbon electrode. A well-defined oxidation peak was obtained in Britton-Robinson (BR) buffer (pH 2.0). The response was evaluated as a function of some variables such as the scan rate, and pH. METHODS A simple, precise, inexpensive and sensitive voltammetric method has been developed for the determination of the cited drugs Olanzapine (OLZ) and Quetiapine fumarate (QUT). RESULTS A linear calibration was obtained from 3 × 10(-8) M to 4 × 10(-6) M and 2 × 10(-8) M to 5 × 10(-6) M, with R. S. D. were 1.6 % and 1.2 % for OLZ and QUT, respectively. The limit of detection (LOD) was 1 × 10(-8) M, while the limit of quantification (LOQ) was 3 × 10(-8) M. CONCLUSION The method was applied to the determination of investigated drugs in urine and serum samples and dosage forms.