Linkage between the Bacterial Acid Stress and Stringent Responses: Structure of the Inducible Lysine Decarboxylase
نویسندگان
چکیده
Review timeline: Submission date: 17 June 2010 Editorial Decision: 14 July 2010 Additional correspondence (editor) 20 July 2010 Revision received: 26 July 2010 Editorial Decision: 27 August 2010 Additional correspondence (author) 02 September 2010 Additional correspondence (editor) 03 September 2010 Additional correspondence (author) 03 September 2010 Additional correspondence (editor) 21 September 2010 Additional correspondence (author) 21 September 2010 Revision received: 02 December 2010 Editorial Decision: 15 December 2010 Revision received: 17 December 2010 Accepted: 21 December 2010
منابع مشابه
Linkage between the bacterial acid stress and stringent responses: the structure of the inducible lysine decarboxylase.
The Escherichia coli inducible lysine decarboxylase, LdcI/CadA, together with the inner-membrane lysine-cadaverine antiporter, CadB, provide cells with protection against mild acidic conditions (pH∼5). To gain a better understanding of the molecular processes underlying the acid stress response, the X-ray crystal structure of LdcI was determined. The structure revealed that the protein is an ol...
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The stringent response regulator ppGpp has recently been shown by our group to inhibit the Escherichia coli inducible lysine decarboxylase, LdcI. As a follow-up to this observation, we examined the mechanisms that regulate the activities of the other four E. coli enzymes paralogous to LdcI: the constitutive lysine decarboxylase LdcC, the inducible arginine decarboxylase AdiA, the inducible orni...
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Escherichia coli is an enteric bacterium that is capable of growing over a wide range of pH values (pH 5-9) and, incredibly, is able to survive extreme acid stresses including passage through the mammalian stomach where the pH can fall to as low as pH 1-2. To enable such a broad range of acidic pH survival, E. coli possesses four different inducible amino acid decarboxylases that decarboxylate ...
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