Synthesis of bicyclic enediynes that possess a photosensitive triggering device and exhibit strong DNA cleaving activity.
نویسندگان
چکیده
The synthesis of a bicyclic enediyne capable of photosensitive triggering and conjugated to a pyrrole-imidazole polyamide is described. Using UV irradiation, this hybrid molecule is shown to exhibit 100-fold stronger potency for DNA cleavage, in an in vitro assay, as compared to the enediyne without the DNA-localizing pyrrole-imidazole.
منابع مشابه
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ورودعنوان ژورنال:
- Chemical communications
دوره 46 32 شماره
صفحات -
تاریخ انتشار 2010