The Goldilocks Model for TCR—Too Much Attraction Might Not Be Best for Vaccine Design
نویسندگان
چکیده
One of the most exciting avenues of translational research today is determining how to program ab T cells of the immune system to treat diseases such as cancer. The main function of T cells is the surveillance of unhealthy cells throughout the body. Because of their specificity, function, and lasting memory, T cells can contribute to the prevention and treatment of many diseases. Two approaches that are being explored to improve T cell responses using different vaccine methods are adoptive cell therapies, in which T cells are expanded and possibly manipulated ex vivo and then reintroduced into the patients [1], and stimulation of the endogenous T cell repertoire [2]. Both hold promise for antigen-specific treatments of diseases.
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