How I treat heparin-induced thrombocytopenia and thrombosis.
نویسنده
چکیده
منابع مشابه
Management of the multiple phases of heparin-induced thrombocytopenia.
The clinical course of heparin-induced thrombocytopenia (HIT) may be separated into five sequential phases: 1. suspected HIT, 2. acute HIT, 3. subacute HIT A, 4. subacute HIT B, and 5. remote HIT. Each phase confronts the clinician with a unique set of management questions. In this review, the phases of HIT are defined and key management questions associated with each phase are discussed. Among...
متن کاملHow I treat How I treat heparin-induced thrombocytopenia and thrombosis
Heparin-induced thrombocytopenia (HIT) is one of the most common and potentially devastating of immune-mediated drug reactions.1 The clinical manifestations of this disorder are initiated by antibodies directed against platelet factor 4 (PF4), which becomes an antigenic target when bound to heparin. The immune complex binds to the Fc RII receptors on circulating platelets and induces platelet a...
متن کاملTreatment of heparin-induced thrombocytopenia: a critical review.
Heparin-induced thrombocytopenia (HIT) is a serious complication of heparin therapy that has a high rate of morbidity (thrombosis and amputation) and mortality. In the past, a number of different anticoagulants have been used to treat HIT in an attempt to prevent these complications. More recently, direct thrombin inhibitors have become popular. This systematic review summarizes the risk for th...
متن کاملSuccessful Use of Intravenous Immunoglobulin G to Treat Refractory Heparin-Induced Thrombocytopenia With Thrombosis Complicating Peripheral Blood Stem Cell Harvest
Heparin-induced thrombocytopenia is a well-known, life-threatening complication that occurs in 5% of patients exposed to heparin. It causes thrombocytopenia in roughly 85% to 90% of affected individuals, with expected recovery in approximately 4 to 10 days following heparin withdrawal. However, there is an entity known as refractory heparin-induced thrombocytopenia with thrombosis in which pati...
متن کاملHeparin induced thrombocytopenia
Abstract Background and Objectives Heparin is still a commonly used anticoagulant in prophylaxis and treatment of thromboembolic events. Heparin-induced thrombocytopenia (HIT) is a life-threating adverse drug reaction of heparin. The diagnosis of HIT is made based on two important criteria, firstly clinical evaluation and secondly laboratory testing. In this comprehensive review, the authors w...
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ورودعنوان ژورنال:
- Blood
دوره 101 1 شماره
صفحات -
تاریخ انتشار 2003