BLIP-II is a highly potent inhibitor of Klebsiella pneumoniae carbapenemase (KPC-2).
نویسندگان
چکیده
β-Lactamase inhibitory protein II (BLIP-II) is a potent inhibitor of class A β-lactamases. KPC-2 is a class A β-lactamase that is capable of hydrolyzing carbapenems and has become a widespread source of resistance to these drugs for Gram-negative bacteria. Determination of association and dissociation rate constants for binding between BLIP-II and KPC-2 reveals a very tight interaction with a calculated (koff/kon) equilibrium dissociation constant of 76 fM (76 × 10(-15) M).
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ورودعنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 57 7 شماره
صفحات -
تاریخ انتشار 2013