The Simultaneous Estimation of Paracetamol and Tolperisone Hydrochloride in Tablet by UV Spectrophotometric Methods

Two methods for simultaneous estimation of Paracetamol and Tolperisone Hydrochloride in combined tablet dosage form have been developed using Water as a solvent. The first UV spectrophotometric method was a determination using the simultaneous equation method at 242.5 nm and 260 nm. The second UV spectrophotometric method is the Q – analysis (absorption ratio) method, which involves the formation of absorbance equation at 254 nm (isoabsorptive point) and at 260 nm the maximum absorption of Tolperisone Hydrochloride. The linearity ranges for Paracetamol and Tolperisone Hydrochloride were 4-12 μg/ml and 2-18 μg/ml respectively. The accuracy of the methods was assessed by recovery studies was found to be 102.03 ± 3.79and 98.93 ± 0.90 for simultaneous equation method and 100.4 ± 1.80 and 99.40 ± 1.25 for Q analysis (absorption ratio) method for Paracetamol and Tolperisone Hydrochloride respectively. These methods are simple, accurate and rapid; those require no preliminary separation and can therefore be used for routine analysis of both drugs in quality control laboratories.