Synthesis and Biological Evaluation of Chlorinated Analogs of Leukotoxin Diol.
نویسندگان
چکیده
This study documents that chlorinated analogs of leukotoxin diol 1, in which the vic-diol has been replaced with vic-chlorides (2), induce caspase 3 activity and apoptosis on HepG2 cells in a dose-dependent manner in analogy to the parent diol. This suggests that chlorides may substitute for hydroxyls in certain lipids as bioisosteres in defined biological settings.
منابع مشابه
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ورودعنوان ژورنال:
- Organic letters
دوره 17 22 شماره
صفحات -
تاریخ انتشار 2015