Emerging Paradigms for the Initiation of Mucin Type Protein O- Glycosylation by the Polypeptide GalNAc Transferase (ppGalNAc T) Family of Glycosyltransferases*
نویسندگان
چکیده
*This work was supported in part by grants from the National Institutes of Health: grants CA78834 (to T.A.G.), P30-CA43703, CA130901 (to S.D.M.) from the NCI, and NIDDK intramural program grant (to L.A.T.). Running head: Initiation of Mucin-Type O-glycosylation Footnote 1 To whom correspondence should be addressed: Dept. of Pediatrics, Case Western Reserve University, School of Medicine, BRB 823, 2109 Adelbert Rd. Cleveland OH 44104-4948. Tel.: 216368-4556; Fax: 216-368-4223; E-mail: [email protected]
منابع مشابه
Emerging paradigms for the initiation of mucin-type protein O-glycosylation by the polypeptide GalNAc transferase family of glycosyltransferases.
Mammalian mucin-type O-glycosylation is initiated by a large family of ∼20 UDP-GalNAc:polypeptide α-N-acetylgalactosaminyltransferases (ppGalNAc Ts) that transfer α-GalNAc from UDP-GalNAc to Ser and Thr residues of polypeptide acceptors. Characterizing the peptide substrate specificity of each isoform is critical to understanding their properties, biological roles, and significance. Presently, ...
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