Helicobacter pylori infection and gastric lymphoma.
نویسنده
چکیده
Gastric lymphoma of mucosa associated lymphoid tissue (MALT) has characteristic clinicopathological features that are different from nodal-type B cell lymphomas. Before a lymphoma can arise within the stomach, MALT has to be acquired as part of a response to an immunological stimulus. In most instances, gastric MALT is acquired in response to infection by Helicobacter pylori. There are several features of MALT lymphoma, such as plasma cell differentiation and follicular colonisation, that suggest that these lymphomas, although demonstrated on the basis of clonality studies to be neoplastic, retain some immunological drive. In vitro studies have shown that co-culturing cells derived from low grade MALT lymphomas with H. pylori results in tumour cell proliferation in a T cell dependant manner. Clinical studies have taken this discovery further and shown that patients with early low grade gastric MALT lymphoma treated with anti-Helicobacter therapy can show regression of their tumours. It is now generally accepted that eradication of H. pylori is a central component of the management of MALT lymphoma.
منابع مشابه
فراوانی نسبی عفونت هلیکوباکترپیلوری در بیماران مبتلا به لنفوم اولیه معده در مراجعین به مراکز پاتولوژی شهر یزد
Introduction: Lymphomas as a group rank seventh as the most leading cause of death in cancers. Stomach is the most common extra nodal site of primary lymphomas. On the other hand, new information demonstrates that MALT lymphoma responds to Helicobacter antibiotic therapy. We therefore decided to determine the frequency of distribution of Helicobacter Pylori infection in primary gastric lymphoma...
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Diagnostic Accuracy of Polyclonal Stool Antigen for Detection of Helicobacter Pylori Infection in Children
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ورودعنوان ژورنال:
- Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]
دوره 171 2 شماره
صفحات -
تاریخ انتشار 1994