The human papillomavirus type 8 E6 protein interferes with NOTCH activation during keratinocyte differentiation.
نویسندگان
چکیده
Cutaneous β-human papillomavirus (β-HPV) E6 proteins inhibit NOTCH signaling by associating with the transcriptional coactivator MAML1. NOTCH has tumor suppressor activities in epithelial cells and is activated during keratinocyte differentiation. Here we report that HPV type 8 (HPV8) E6 subverts NOTCH activation during keratinocyte differentiation by inhibiting RBPJ/MAML1 transcriptional activator complexes at NOTCH target DNA. NOTCH inhibition impairs epithelial differentiation and may thus contribute to β-HPV replication and viral oncogenesis.
منابع مشابه
Cutaneous β-human papillomavirus E6 proteins bind Mastermind-like coactivators and repress Notch signaling.
The Notch signaling pathway is a key determinant in keratinocyte differentiation and growth cycle arrest, and has been reported to have a tumor suppressor function in skin. The papillomavirus life cycle is intricately linked to the differentiation status of keratinocytes. Papillomaviruses are associated with benign proliferative epithelial lesions in their respective hosts. Although human papil...
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ورودعنوان ژورنال:
- Journal of virology
دوره 87 8 شماره
صفحات -
تاریخ انتشار 2013