INTEGRATION OF HTLV - I IN ATL Eco M Pst I T P 4 5 6 T P 4 5 6 9 . 4 - 7 " - - 0 1 - 2 . 5 0 - 1
نویسندگان
چکیده
The proviral DNA of human T-cell lymphotrophic virus type I (HTLV-I) is known to be integrated monoclonally in the malignant cells of adult T-cell leukemia/lymphoma (ATL), which is a peripheral T-cell malignancy caused by this virus. We studied the relationship between the integration patterns of HTLV-I and clinical characteristics in 89 patients with ATL. The proviral DNA of HTLV-I was examined by the standard Southern blot analysis using the endonucleases € d l and Pst 1. One clear band of greater than 9 kb was detected in most of the patients ( 8 3 cases) when cellular DNA was digested with EcoRI. On the other hand, extraordinary integration patterns of HTLV-I proviral DNA were detected in 6 patients; 3 of them showed two bands, while the other 3 showed one band smaller than 9 kb. When cellular DNA was digested with Pst 1, the band patterns of these patients were quite different from those of typical patients. The patients with the extraordinary integration patterns had clinical characteristics dissimilar to those of the other 83 patients with
منابع مشابه
S/sup 4/W: globally optimized design of wireless communication systems - Parallel and Distributed Processing Symposium., Proceedings International, IPDPS 2002, Abstracts a
! "# $ ! ! % & ' () * + ,! . 0/ 1 2 ! "3 4 5 & "# ! + % "3 & 5 6 "875 3 9, :; 5 0 < =4 ! "# >@?A BA% & C ! ! D % E ! "GFIH. 5J-KML-NPO HM / , 9 QJ-KML-NR & S 7MTU 9 WV; X !(U & 9 2 &,ZY& !(U% [ "3 \O ] ^ ^ _ SRF` # D %D & & % ,a ! b 8 5 0 _ Hc , d + ! e = 5 % & -"# , 0 W (U & & 9 . f hg i i 6j & , hk2 :;(U 7C% 0() ! 7mln &(Uo :; [ ! ! 9 D> Y&(U 5 ! p75(U &% & @75 U q mrGLsHMtu?vO :; , &,w% , x,...
متن کاملFormation times of Meteorites and Lunar Samples
Atopic abundances and the reso lu t ion of small t ime differ ences in the formation of p lane ta ry objects, Earth Planet. Sci Lett., 5, 3 6 1 3 7 6 , 1 9 6 9 . fmn R ®-> Heavy rare gases in silicates f rom t h e Esterville lesosiderite,X Geophys. Res., 71, 2 8 1 5 2 8 2 9 , 1966 . toin R. 0 . , Trapped neon in meteor i t e s , Earth Planet. Sci ' letl 1 1 3 1 8 , 1967 . Pepin R 0 . , and P. ...
متن کاملWeb Document Summarization by Context
! #"$ %& '# ( %&%) * +, .'0/1 &"$ ' 2 3 $ 4 )" '# $5 6 7 $ 8 #" %& '# 9 #:; 2 $" < ' = * %) * ') $5 > *"$ , ? @ %A " '# '# ( 0 B B ? 3 #" %& $' CB ' DE , 7 ! F ,/ G 4 C = * H * > I JHK !' $HL %M%) . +, * 'G :I"$ '# $5 9 B N F %& /) ?O P 9 ' M Q 4"$ '# '# R *' S 9" '# $5 Q ' 7 6 " ' 1 ' 6 B R ' BF: '7 Q $B2 $%& '# T Q" '# $5 ,/VUW C X ,HX'7 * C %&%) . 2 $ , Y 'I M"$ '# $5 9 * ? *B B :I%4 "> I%& ...
متن کاملSupport for Service Composition in
! #"$ %& ' ( ) * * + -, ./ 0 ,1 2,3 4 5.6 # 7)8 ./ 4 /,* 9 :<; = 2,* 9 > = ,* ?7@ A *; B C ( 2 ,# D C B9 ) C FEG ( 0 ) 2H ?I=./ 4 2,* J ) : "K * L,J%*,# NMO *"P %& QJRAH ,* ( S #"P ; ? 4 % T,1 SU V: 4 B 8W C ; O X8X,* CM ( Y ,# X8 ?,* & B 8Z,* ,* ? B Q=[5 T \ ,* ) 28*.6 ],# B*; P ,1 ^ 6[5 C ^[5 V [N "0 ?,* _ ; 4 ; >EG`Na I C 6 ...
متن کاملA Set of 74 Test Functions for Nonlinear Equation Solvers
This report gives 74 funct ions appropriate to use to test programs which solve one nonl inear equat ion in ofie real variable . The funct ions are given in a Fortran subrout ine as a two-dimensional array . A SET OF 74 TEST FUNCTIONS FOR WO* 'LINEAR F.OUATION SOLVERS INTRODUCTION AMP SUT1MA n Y: Tliis report «ives 74 functions in FORTRAN code which have been gathered as a set of test funct ion...
متن کامل