Differential effects of selective PDE5 inhibitors in rat cerebral arteries in vitro and in vivo
نویسندگان
چکیده
Address: 1Department of Neurology, Glostrup Hospital University of Copenhagen, Glostrup Denmark, 2Lundbeck Foundation Centre for Neurovascular Research, Glostrup Hospital, Glostrup Denmark, 3Dept. Clinical Biochemistry, Glostrup Research Park, Glostrup Hospital, Glostrup Denmark, 4Division of Experimental Vascular Research, Department of Internal Medicine, University Hospital of Lund, Lund, Sweden and 5Dept. Clinical Experimental Research, Glostrup Research Park, Glostrup Hospital, Denmark
منابع مشابه
Differential vasoactive effects of sildenafil and tadalafil on cerebral arteries.
Phosphodiesterase 5 (PDE5) is associated with migraine pathophysiology, stroke recovery and vasospasm treatment. The potential vascular interplay of PDE5 inhibitors sildenafil, tadalafil and UK-114,542 was studied by intra- versus extra-luminal administration in rat middle cerebral arteries in vitro and on middle meningeal arteries in vivo. By Western blot PDE5 was detected in both cerebral and...
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Sildenafil (Viagra), a selective inhibitor of phosphodiesterase 5 (PDE5), induces headache and migraine. Although previously supposed to be a "vascular" headache, no significant cerebral artery dilatation was found in vivo. Thus, we hypothesised that PDE5 may not be present or that sildenafil is less effective on the cGMP hydrolysis in cerebral arteries, and that sildenafil may not be an effect...
متن کاملDifferential vasoactive effects of sildenafil and tadalafil on cerebral arteries –relevant to migraine?
Background Phosphodiesterase 5 (PDE5) is associated with migraine pathophysiology, stroke recovery and vasospasm treatment [1,2]. We have shown previously that vasodilatation was not a prerequisite for migraine induction; sildenafil elicited migraine-like attacks in migraine patients without measurable changes in intraor extracerebral artery diameter. Further, sildenafil was found to not affect...
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Objective(s): Recently, we showed that some new synthetic compounds structurally related to cilostamide (4-(1,2-dihydro-2-oxoquinolin-6-hydroxy)- N-cyclohexyl-N-methylbutanamide), a selective phosphodiesterase 3 (PDE3) inhibitor, produce inotropic effect comparable to that of IBMX (3-isobutyl-1-methylxanthine), a non-selective PDE inhibitor, but with differential chronotropic effect. In this in...
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Aims:Memory deficit is the most visible symptom of cerebral ischemia. The hippocampus is sensitive against cerebral ischemia. Oxidative stress and inflammation are involved in the pathological process after cerebral ischemic injury. Paroxetine has anti-oxidative and anti-inflammatory effects. In this study the effect of paroxetine on memory deficit after cerebral ischemia was investigated. Meth...
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