PT664. Associations between actigraphy-assessed sleep, inflammatory markers, and insulin resistance in the Midlife Development in the United States (MIDUS) study

Purpose: Insomnia is one of the most prevalent symptoms experienced by cancer patients. The goal of this study was to investigate the severity of insomnia and the risk factors of insomnia in cancer patients who referred to specialized psychooncology clinic. Method: A total of 167 cancer patients who referred to psychooncology clinic in Ajou University Hospital was investigated. Insomnia was measured using the Insomnia Severity Index (ISI). For the investigation of risk factors, we considered demographic factors, clinical factors, Distress Thermometer (DT), Functional Assessment of Cancer Therapy – General (FACT-G), and Hospital Anxiety and Depression Scale (HADS). The risk factors of insomnia were evaluated using multiple regression analysis. Results: Of 167 patients, 132 (79.0%) were females and 35 (21.0%) were males, with the average age at presentation of 51.1 years old. Most common cancers were breast (42.1%), gastrointestinal (16.4%), and gynecologic (18.4%). We defined insomnia group with over 15 score of ISI. Insomnia group (N=73, 43.7%) had more psychiatric past history and showed significantly higher distress, anxiety, and depression and lower physical, emotional, and social wellbeing than non-insomnia group. After adjusting the effect of psychiatric past history, the significant risk factors of insomnia were distress, anxiety, physical wellbeing, and social wellbeing and accounted for 38.7% of the variance in insomnia. Conclusion: Insomnia is prevalent in cancer patients who referred to psychooncology clinic. The modifiable risk factors of insomnia in these patients were distress, anxiety, physical wellbeing, and social wellbeing. Early assessment and intervention strategies for these factors could prevent from becoming chronic insomnia in cancer patients. PT663 Comparison of wearable activity tracker to actigraphy for sleep evaluation and circadian rhythm measurement. Hyun-Ah Lee1, Joung-Ho Moon2, Heon-Jeong Lee1, 2, 3, Taek Lee4, Hoh Peter In4, Chul-Hyun Cho1, 3, Leen Kim1, 3* 1Department of Psychiatry, Korea University College of Medicine; 2Department of Biomedical Sciences, Korea University College of Medicine; 3Sleep-Wake Disorders Center, Korea University Anam Hospital; 4Department of Computer Science, Korea University College of Information and Communications, Seoul, South Korea *Corresponding author.