GS - 8374 , a novel HIV protease inhibitor , 1 does not alter glucose homeostasis in cultured adipocytes 2 or in a healthy rodent model system 3 4 5
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چکیده
Address correspondence to: 12 13 Paul W. Hruz, 14 Washington University School of Medicine, 15 660 S. Euclid Ave., Campus Box 8208, 16 St. Louis, MO 63110. 17 Tel.: 314-286-2797; Fax: 314-286-2892; E-mail: [email protected] . 18 19 Christian Callebaut, 20 Gilead Sciences, 21 333 Lakeside Dr., 22 Foster City, CA 94404. 23 Tel: 650-522-6362 Fax: 650-522-5143; Email: [email protected] 24 25 26 Short title: Effect of GS-8374 on glucose homeostasis 27 Copyright © 2011, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved. Antimicrob. Agents Chemother. doi:10.1128/AAC.01184-10 AAC Accepts, published online ahead of print on 18 January 2011
منابع مشابه
GS-8374, a novel HIV protease inhibitor, does not alter glucose homeostasis in cultured adipocytes or in a healthy-rodent model system.
Adverse effects induced by HIV protease inhibitors (PIs) are a significant factor in limiting their clinical success. PIs directly contribute to peripheral insulin resistance and alterations in lipid metabolism. GS-8374 is a novel PI with potent antiretroviral activity and a favorable resistance profile. Here we report on the potential of GS-8374 to adversely affect glucose and lipid homeostasi...
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GS-8374 is a potent HIV protease inhibitor (PI) with a unique diethyl-phosphonate moiety. Due to a balanced contribution of enthalpic and entropic components to its interaction with the protease (PR) active site, the compound retains activity against HIV mutants with high-level multi-PI resistance. We report here the in vitro selection and characterization of HIV variants resistant to GS-8374. ...
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