CD2 expression and the PML-RAR gene.
نویسندگان
چکیده
منابع مشابه
Correlation of CD2 expression with PML gene breakpoints in patients with acute promyelocytic leukemia.
The chromosomal translocation t(15;17)(q22:21) of acute promyelocytic leukemia (APL) fuses PML, a novel gene, with RAR alpha, a retinoic acid receptor gene. PML-RAR hybrid transcripts were studied in 18 cases of APL using RNA-PCR. Two forms were noted: one designated 5', producing a 439-bp chimeric fragment, and a 3' form, producing a pair of fragments of 765 bp and 909 bp. 5' forms were found ...
متن کاملCD2 expression and PML/RAR-alpha transcripts in acute promyelocytic leukemia.
The report by Claxton et all describes a close correlation between the type of aberrant mRNA transcripts for PML/RAR-a in 2 1 patients with acute promyelocytic leukemia (APL) and expression of CD2, a surface antigen of the Ig superfamily of cellular adhesion molecules that is generally associated with a T-lymphocyte phenotype.2 Since we have recently studied a number of patients with APL using ...
متن کاملA retinoid-resistant acute promyelocytic leukemia subclone expresses a dominant negative PML-RAR alpha mutation.
The unique t(15;17) of acute promyelocytic leukemia (APL) fuses the PML gene with the retinoic acid receptor alpha (RAR alpha) gene. Although retinoic acid (RA) inhibits cell growth and induces differentiation in human APL cells, resistance to RA develops both in vitro and in patients. We have developed RA-resistant subclones of the human APL cell line, NB4, whose nuclear extracts display alter...
متن کاملPML protein expression in hematopoietic and acute promyelocytic leukemia cells.
Acute promyelocytic leukemia (APL) is thought to be caused by the t(15,17) translocation that fuses the PML gene to that of the retinoic acid receptor alpha (RAR alpha) and generates a PML/RAR alpha fusion protein. Yet, paradoxically, APL cells are exquisitely sensitive to retinoic acid (RA), as they terminally differentiate upon RA exposure. In this report, we have examined the expression of P...
متن کاملThe PML/RAR alpha oncoprotein is a direct molecular target of retinoic acid in acute promyelocytic leukemia cells.
Acute promyelocytic leukemia (APL) is characterized by the translocation, t(15;17) and the expression of a PML/RAR alpha fusion protein that is diagnostic of the disease. There is evidence that PML/RAR alpha protein acts as a dominant negative inhibitor of normal retinoid receptor function and myeloid differentiation. We now show that the PML/RAR alpha fusion product is directly downregulated i...
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ورودعنوان ژورنال:
- Blood
دوره 81 8 شماره
صفحات -
تاریخ انتشار 1993