An Independent Critique of Low-carb Diets: Cracking Down on Eggs and Cholesterol
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چکیده
This year marks the 100th year anniversary of when Nik olai Anichkov firs t used the rabbit model to show that the ingestion of dietary cholesterol alone is a primary cause of atheroscleros is. Since 1913 it has been demonstrated in thousa nds of animal experiments that the feeding of cholesterol, including in the form of fresh egg yolk accelerates the development of a theroscler osis in virtually every vertebrate species that has been sufficiently challenged. This includes ma mmalian, avia n and f ish speciesherbivores, omnivores a nd carnivores, a nd over one dozen different species of nonhuman prima tes.
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Compared with saturated fatty acids, dietary monounsaturated fatty acids and carbohydrates increase atherosclerosis and VLDL cholesterol levels in LDL receptor-deficient, but not apolipoprotein E-deficient, mice.
Heart-healthy dietary recommendations include decreasing the intake of saturated fatty acids (SFA). However, the relative benefit of replacing SFA with monounsaturated fatty acids (MUFA), polyunsaturated fatty acids (PUFA), or carbohydrates (CARB) is still being debated. We have used two mouse models of atherosclerosis, low density lipoprotein receptor-deficient (LDLRKO) and apolipoprotein E-de...
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