Nucleotide sequence of cDNA for human aldose reductase.

The sequence of human foetal liver aldose reductase cDNA obtained from a \-gtlO library 1s presented. This cDNA encodes a protein of 316 ami no adds with a 45 bp 5'-non coding region and a 356 bp 3 1 non coding region. Aldose reductase Is of wide clinical Interest 1n that Inhibitors may prevent the complications associated with diabetes melHtus. The cDNA clone was Identified using ol1gonucleot1des based on rat lens(l) cDNA and bovine lens protein sequence(2). Aldose reductase constitutes one member of the aldo-keto reductase enzyme family. The data herein confirm recent assignments of sequence to various members of this NADPH-dependent carbonyl oxidoreductase superfam1ly(3).