Neurobiology of Disease High-Resolution Electrical Stimulation of Primate Retina for Epiretinal Implant Design
نویسندگان
چکیده
Chris Sekirnjak,1 Pawel Hottowy,2 Alexander Sher,2 Wladyslaw Dabrowski,3 Alan M. Litke,2 and E. J. Chichilnisky1 1Systems Neurobiology Laboratory, The Salk Institute for Biological Studies, San Diego, California 92037, 2Santa Cruz Institute for Particle Physics, University of California, Santa Cruz, California 95064, and 3Faculty of Physics and Applied Computer Science, AGH University of Science and Technology, 23 30-059, Krakow, Poland
منابع مشابه
High-resolution electrical stimulation of primate retina for epiretinal implant design.
The development of retinal implants for the blind depends crucially on understanding how neurons in the retina respond to electrical stimulation. This study used multielectrode arrays to stimulate ganglion cells in the peripheral macaque retina, which is very similar to the human retina. Analysis was restricted to parasol cells, which form one of the major high-resolution visual pathways in pri...
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Epiretinal prostheses for treating blindness activate axon bundles, causing large, arc-shaped visual percepts that limit the quality of artificial vision. Improving the function of epiretinal prostheses therefore requires understanding and avoiding axon bundle activation. This study introduces a method to detect axon bundle activation on the basis of its electrical signature and uses the method...
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Lauren H. Jepson,1,2 Paweł Hottowy,3 Keith Mathieson,4 Deborah E. Gunning,4 Władysław Dąbrowski,3 Alan M. Litke,5 and E. J. Chichilnisky1 1Systems Neurobiology Laboratories, Salk Institute for Biological Studies, La Jolla, California 92037, 2Bioengineering Department, University of California, San Diego, California 92093, 3AGH University of Science and Technology, Faculty of Physics and Applied...
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Natural vision relies on spatiotemporal patterns of electrical activity in the retina. We investigated the feasibility of veridically reproducing such patterns with epiretinal prostheses. Multielectrode recordings and visual and electrical stimulation were performed on populations of identified ganglion cells in isolated peripheral primate retina. Electrical stimulation patterns were designed t...
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PURPOSE Since 2000, several groups have initiated chronic studies, implanting electronic retinal prostheses into the blind eyes of patients with retinitis pigmentosa to produce formed vision. DESIGN A review and comparison of their techniques and results. METHODS The 4 groups reviewed comprise 2 epiretinal and 2 subretinal groups. Visual function results reported in their publications durin...
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