Disease specific enrichment of circulating let-7 family microRNA in MuSK+ myasthenia gravis

نویسندگان

  • Tanel Punga
  • Emanuela Bartoccioni
  • Marta Lewandowska
  • Valentina Damato
  • Amelia Evoli
  • Anna Rostedt Punga
چکیده

Myasthenia gravis (MG) patients with antibodies against the muscle specific tyrosine kinase (MuSK+) have predominantly involvement of cranio-bulbar muscles and do not display thymus pathology, as do acetylcholine receptor antibody seropositive (AChR+) MG patients. In search of novel biomarkers for MuSK+ MG, we evaluated circulating serum microRNAs. Four analyzed microRNAs were specifically elevated in MuSK+ MG patient serum samples: let-7a-5p, let-7f-5p, miR-151a-3p and miR-423-5p. The circulating microRNA profile in MuSK+ MG differs from the profile previously observed in the serum of AChR+ MG, thus indicating the etiological difference between these two entities. We propose that the identified microRNAs could serve as potential serum biomarkers for MuSK+ MG.

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عنوان ژورنال:
  • Journal of Neuroimmunology

دوره 292  شماره 

صفحات  -

تاریخ انتشار 2016