Notch Signalling and Cellular Fate Choices: A Short Review
نویسنده
چکیده
During mammalian central nervous system (CNS) development, an enormous variety of cell types are generated. This cell diversity is due in part to asymmetrical cell division. Asymmetrical segregation of Numb, a cell-determinant protein, can result in the differential activation of the Notch pathway. The Notch pathway defines one of the few fundamental signalling pathways that govern metazoan development. Notch signals link the fate decisions of one cell to those of its neighbours. Notch activation has a profound effect on many aspects of nervous system development. Here we present a brief overview of Notch signalling and reiterate some relevant questions relating to the Notch pathway.
منابع مشابه
Cell movements controlled by the Notch signalling cascade during foregut development in Drosophila.
Notch signalling is an evolutionarily conserved cell interaction mechanism, the role of which in controlling cell fate choices has been studied extensively. Recent studies in both vertebrates and invertebrates revealed additional functions of Notch in proliferation and apoptotic events. We provide evidence for an essential role of the Notch signalling pathway during morphogenetic cell movements...
متن کاملDev121145 3649..3660
NOTCH signalling is an evolutionarily conserved pathway involved in intercellular communication essential for cell fate choices during development. Although dispensable for early aspects of mouse development, canonical RBPJ-dependent NOTCH signalling has been shown to influence lineage commitment during embryonic stem cell (ESC) differentiation. NOTCH activation in ESCs promotes the acquisition...
متن کاملWnt/Notch signalling and information processing during development.
The Wnt and Notch signalling pathways represent two major channels of communication used by animal cells to control their identities and behaviour during development. A number of reports indicate that their activities are closely intertwined during embryonic development. Here, we review the evidence for this relationship and suggest that Wnt and Notch ('Wntch') signalling act as components of a...
متن کاملNew Insights into the Mechanism of Notch Signalling in Fibrosis
The Notch pathway is an evolutionary conserved signalling mechanism that regulates cellular fate and development in various types of cells. The full spectrum of Notch effects has been well studied over the last decade in the fields of development and embryogenesis. But only recently several studies emphasized the involvement of the Notch signalling pathway in fibrosis. This review summarizes th...
متن کاملCoordinated control of Notch/Delta signalling and cell cycle progression drives lateral inhibition-mediated tissue patterning
Coordinating cell differentiation with cell growth and division is crucial for the successful development, homeostasis and regeneration of multicellular tissues. Here, we use bristle patterning in the fly notum as a model system to explore the regulatory and functional coupling of cell cycle progression and cell fate decision-making. The pattern of bristles and intervening epithelial cells (ECs...
متن کامل