Effect of Ethanol Leaf-Extract of Annona muricata on Serum Total Protein and Albumin Concentrations in Albino Rats

نویسندگان

  • C. E. Offor
  • B. Chukwu
  • I. O. Igwenyi
  • P. C. Ugwu Okechukwu
چکیده

Annona muricata has been reported to treat several ailments such as headaches, insomnia, cystitis, liver problems, diabetes, hypertension, inflammation, dysentery, among others. The present study investigated the effect of ethanol leaf-extract of Annona muricata on serum total protein and albumin concentrations in albino rats using spectrophotometric methods. Twenty albino rats were randomly assigned into four groups (A, B, C andD) with five rats in each. Doses of 200mg/kg, 400mg/kg and600mg/kg body weight of the extract were administered to animals in groups B, C andD respectively via oral intubation twice daily for fourteen consecutive days while group A served as control and received no extract. Blood of the animals were collected on the 15 day following the last day of administration through heart puncture. There was no significant effect th (p > 0.05) on serum total protein and albumin concentrations except at the dose of 600mg/kg.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Hepatoprotective activity of Annona muricata Linn. and Polyalthia cerasoides bedd.

The hepatoprotective effect of Annona muricata and Polyalthia cerasoides (Annonaceae) were monitored by estimating the serum transaminases (SGOT and SGPT), serum alkaline phosphatase (SALP), liver and brain lipid peroxidation (LOP) and their total protein content. Both drugs at a dose of 100 μg/kg significantly prevented the increase in serum transaminases, SALP, liver and brain LOP and decreas...

متن کامل

Protective Effect of Cordia Myxa Extract on Changes in Body Weight, Serum Proteins, Albumin and Liver Histology of Adult Male Rats Induced by Cadmium Chloride Toxicity

Background: The present study investigated the protective effect of C. myxa extract on the liver biochemical and histologic changes induced by cadmium chloride (CdCl2) in adult male rats. Methods: We used 48 adults male Wistar rats, divided into 6 groups of 8. Control group received water and normal food. Sham group 1 received 2 mg/kg of CdCl2 for 35 days intraperitoneally. In Addition, Sh...

متن کامل

Aqueous Leaf Extract of Heliotropium Indicum Ameliorates Hyperglycaemia-Induced Tissue Complications in Albino Rats

Background: Heliotropium indicum is used by traditional medical practitioners in North Central Nigeria for the management of ailments including diabetes. However, the folkloric use of H. indicum as antidiabetic has been asserted, but its roles on the hyperglycemia-induced organ-specific complications are not yet scientifically proven. Thus, ameliorative effect of aqueous leaf extract of H. indi...

متن کامل

Ethanol Extract of Annona Muricata. L Induces liver Cancer Cell Apoptosis through ROS Pathway

The study investigated the underlying molecular mechanisms of ethanol extract of Annona muricata. L induced liver cancer cell apoptosis. The anti-proliferative effect of ethanol extract of Annona muricata. L was evaluated by MTT assay. Flow cytometry was used to detect the cell cycle and apoptosis. TUNEL assay was used to confirm cell apoptosis. DCFH-DA fluorescent probe can detect the level of...

متن کامل

Protective Effect of Ricinus communis Leaves Extract on Carbon Tetrachloride Induced Hepatotoxicity in Albino Rats

       Ricinus communis Linn. (Euphorbiaceae) is a soft wooded tree widely prevalent throughout tropics regions of the world which have a warm temperature. In the Indian system of medicine, the leaves, roots and seed oil of this plant have been used for the treatment of inflammation and liver disorders for a lo...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2015