Direct synthesis of chrysosplenol D.
نویسندگان
چکیده
An aldol condensation and an Algar-Flynn-Oyamada oxidative cyclization were key steps in the direct synthesis of chrysosplenol D, an efflux pump inhibitor that can potentiate the activity of commercially important antibiotics and antimalarials.
منابع مشابه
Antiseptic activity and phenolic constituents of the aerial parts of Vitex negundo var. cannabifolia.
Four phenolics, salviaplebeiaside (1), γ-tocopherol (2), chrysosplenol-D (4), and isovitexin (5), along with α-tocoquinone (3) and β-sitosterol (6) were isolated from the aerial parts of Vitex negundo var. cannabifolia. The isolation was performed using bio-assay tracking experiments. The structures of compounds 1-5 were established by spectroscopic means. The antibacterial activities of the co...
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ورودعنوان ژورنال:
- Journal of natural products
دوره 71 11 شماره
صفحات -
تاریخ انتشار 2008