Indole Based Alkaloid in Cancer: An Overview
نویسندگان
چکیده
Indole alkaloids are well characterized for diverse activities. Meanwhile, the present scenario of disease depicting a different story, urge a call for novel scaffolds and pharmacophores. In recent years, indole based alkaloids gain significant importance in cancer chemotherapy and used as an adjuvant especially in case of Vinca alkaloids. These reports encourage the researchers for new finding related to indole based alkaloids to retrieve better scaffold for designing and synthesis of anticancer agents. However we tried to compile the literatures which cover the recent reports and updates of indole based alkaloids targeting in cancer. Moreover this review paper brings new dimension and interface between the indole based alkaloids and their valuable commitment towards cancer targeting.
منابع مشابه
Goniomitine: An Overview on the Chemistry of This Indole Alkaloid
This paper reports an overview on the chemistry of the indole alkaloid goniomitine focusing, mainly, on the methods of synthesis related to this natural product and analogs.
متن کاملPharmacological properties of some 3-substituted indole derivatives, a concise overview
Indole is a nitrogen-containing heterocycle. It is a very important motif in agriculture and pharmacy. Many compounds containing indole moiety has been isolated form nature. It is also an important part in natural alkaloids. Tryptophan is an amino acid which posses indole. 3-Sustituted indoles are the main group of its derivatives. Because the wide-spread application of 3-substituted indolic co...
متن کاملDe novo production of the plant-derived alkaloid strictosidine in yeast.
The monoterpene indole alkaloids are a large group of plant-derived specialized metabolites, many of which have valuable pharmaceutical or biological activity. There are ∼3,000 monoterpene indole alkaloids produced by thousands of plant species in numerous families. The diverse chemical structures found in this metabolite class originate from strictosidine, which is the last common biosynthetic...
متن کاملPolycyclic indole alkaloid-type compounds by MCR.
Polycyclic indole moieties are often part of bioactive natural or synthetic products, however traditionally have to be synthesized over several steps involving time consuming sequential multi-step syntheses. We herein communicate an efficient and flexible 2-step procedure to complex multicyclic indole alkaloid-type compounds involving Ugi MCR and Pictet-Spengler reaction.
متن کاملThe Alkaloid Alstonine: A Review of Its Pharmacological Properties
Indole compounds, related to the metabolism of tryptophan, constitute an extensive family, and are found in bacteria, plants and animals. Indolic compounds possess significant and complex physiological roles, and especially indole alkaloids have historically constituted a class of major importance in the development of new plant derived drugs. The indole alkaloid alstonine has been identified a...
متن کامل