Facile construction of three contiguous stereogenic centers via dynamic kinetic resolution in asymmetric transfer hydrogenation of quinolines.

نویسندگان

  • Mu-Wang Chen
  • Xian-Feng Cai
  • Zhang-Pei Chen
  • Lei Shi
  • Yong-Gui Zhou
چکیده

An efficient and facile route to chiral tetrahydroquinolines with three contiguous stereogenic centers via a dynamic kinetic resolution process has been successfully developed by using chiral phosphoric acid as catalyst and Hantzsch ester as the hydrogen source with up to 89% ee.

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عنوان ژورنال:
  • Chemical communications

دوره 50 83  شماره 

صفحات  -

تاریخ انتشار 2014