The clinical relevance of measuring NRBC in the XN-CBC

blood cell lineage which still contain a nucleus; they are also known as erythroblasts or – obsolete – normoblasts. In healthy adults and older children, NRBC can only be found in blood-building bone marrow where they mature. Their appearance in peripheral blood points to extramedullary erythropoiesis (outside the bone marrow) or disruption of the blood – bone marrow barrier. Both possible scenarios can only be found in the course of a severe disease. Physiologically, NRBC occur in peripheral blood only in neonates and premature babies.