VASCULAR BIOLOGY Different role of CD73 in leukocyte trafficking via blood and lymph vessels
نویسندگان
چکیده
1MediCity Research Laboratory, University of Turku, Turku, Finland; 2Department of Oncology, University of Turku, Turku, Finland; 3Department of Dermatology, Innsbruck Medical University, Innsbruck, Austria; 4National Institute of Health and Welfare, Turku, Finland; 5Department of Medical Biochemistry and Genetics, University of Turku, Turku, Finland; and 6Department of Medical Microbiology and Immunology, University of Turku, Turku, Finland
منابع مشابه
Different role of CD73 in leukocyte trafficking via blood and lymph vessels.
CD73 is involved in the extracellular ATP metabolism by dephosphorylating extracellular AMP to adenosine and thus regulating permeability of the blood vessels and leukocyte traffic into the tissues. It is also present on lymphatic vessels where its distribution and function have not been characterized. We found that CD73 is expressed on a subpopulation of afferent lymph vessels but is absent on...
متن کاملVAP-1 and CD73, endothelial cell surface enzymes in leukocyte extravasation.
Leukocyte extravasation from the blood into tissues is crucial for normal immune surveillance and in inflammation. Traditionally molecules belonging to selectin, chemokine, integrin, and immunoglobulin super families are thought to mediate the multiple adhesive and activation events needed for a successful emigration cascade. Recently, emerging evidence suggests that enzymes expressed on the su...
متن کاملEcto-5' nucleotidase (CD73)-mediated adenosine generation and signaling in murine cardiac allograft vasculopathy.
Ecto-5'-nucleotidase (CD73) catalyzes the terminal phosphohydrolysis of 5'-adenosine monophosphate and is widely expressed on endothelial cells where it regulates barrier function. Because it is also expressed on lymphocytes, we hypothesized that it modulates vascular immune regulation under homeostatic conditions and dysregulation under stress conditions such as cardiac allotransplantation. In...
متن کاملP 154: The Role of Inflammation in the Seizure Occurrence
Most common hypotheses of seizure initiation are increased neural excitation, decreased inhibition or both. But, the conditions that lead to these activation states not to be clear yet. Recent studies challenge traditional concepts and indicate new evidence that a key epileptogenic process may actually begin in the blood vessel. Seizures could be initiate by a variety of insults to the brain, s...
متن کاملLocal induction of lymphangiogenesis with engineered fibrin-binding VEGF-C promotes wound healing by increasing immune cell trafficking and matrix remodeling.
Lymphangiogenesis occurs in inflammation and wound healing, yet its functional roles in these processes are not fully understood. Consequently, clinically relevant strategies for therapeutic lymphangiogenesis remain underdeveloped, particularly using growth factors. To achieve controlled, local capillary lymphangiogenesis with protein engineering and determine its effects on fluid clearance, le...
متن کامل