Synthesis of novel pyrophosphorothiolate-linked dinucleoside cap analogues in a ball mill.

نویسندگان

  • Olga Eguaogie
  • Leonie A Cooke
  • Patricia M L Martin
  • Francesco Ravalico
  • Louis P Conway
  • David R W Hodgson
  • Christopher J Law
  • Joseph S Vyle
چکیده

Michaelis-Arbuzov reactions of S-aryl disulfide derivatives of 3'-thiothymidine or 5'-thioadenosine with tris(trimethylsilyl) phosphite proceeded in high yields to the corresponding phosphorothiolate monoesters. Subsequent hydrolytic desilylation and phosphate coupling were effected in one-pot using liquid-assisted grinding in a vibration ball mill. Novel 3',5'- and 5',5'-pyrophosphorothiolate-linked dinucleoside cap analogues were thereby prepared.

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عنوان ژورنال:
  • Organic & biomolecular chemistry

دوره 14 4  شماره 

صفحات  -

تاریخ انتشار 2016