Biosynthesis of polybrominated aromatic organic compounds by marine bacteria
نویسندگان
چکیده
Polybrominated diphenyl ethers (PBDEs) and polybrominated bipyrroles are natural products that bioaccumulate in the marine food chain. PBDEs have attracted widespread attention because of their persistence in the environment and potential toxicity to humans. However, the natural origins of PBDE biosynthesis are not known. Here we report marine bacteria as producers of PBDEs and establish a genetic and molecular foundation for their production that unifies paradigms for the elaboration of bromophenols and bromopyrroles abundant in marine biota. We provide biochemical evidence of marine brominases revealing decarboxylative-halogenation enzymology previously unknown among halogenating enzymes. Biosynthetic motifs discovered in our study were used to mine sequence databases to discover unrealized marine bacterial producers of organobromine compounds.
منابع مشابه
Hydroxylated polybrominated diphenyl ethers in Baltic Sea biota Natural production, food web distribution and biotransformation
" When you can't run anymore, you crawl, and when you can't do that, you find someone to carry you "-Joss Whedon's Firefly ep.12-Till alla er som hjälpt till att bära i List of papers This thesis is based on the following papers, referred to in the text by their roman numerals, I-IV: I Lindqvist D., Dahlgren E., and Asplund L. (2017) Biosynthesis of hydroxylated polybrominated diphenyl ethers a...
متن کاملPolybrominated Diphenyl Ethers Furans Polychlorinated Biphenyls Heavy Metals Polycyclic Aromatic Hydrocarbons Organophosphate Pesticides Trihalomethanes Organochlorine Pesticides Volatile Organic Compounds Similar Toxicological Properties and/or Effects Allergic Contact Sensitizers Hepatotoxicants Genetic Carcinogens Immunotoxicants Nongenetic Carcinogens Nephrotoxicants Cardiovascular Toxicants
متن کامل
Gas chromatography retention data of environmentally relevant polybrominated compounds.
Polybrominated organic compounds are ubiquitous throughout the environment. This generic term comprises several classes of brominated flame retardants (e.g., polybrominated diphenyl ethers, polybrominated biphenyls, hexabromocyclododecane, dibromopropyltribromophenyl ether, 1,2-bis(2,4,6-tribromophenoxy)ethane) as well as a range of marine halogenated natural products (HNPs). Here we present ga...
متن کاملPolybrominated diphenyl ethers in marine ecosystems of the American continents: foresight from current knowledge.
Polybrominated diphenyl ethers (PBDEs) are a class of synthetic halogenated organic compounds used in commercial and household products, such as textiles, furniture, and electronics, to increase their flame ignition resistance and to meet fire safety standards. The demonstrated persistence, bioaccumulation, and toxic potential of these compounds in animals and in humans are of increasing concer...
متن کاملFluorescence techniques for the determination of polycyclic aromatic hydrocarbons in marine environment: an overview
PAHs are a class of organic compounds, which are included in the wider family of polycyclic aromatic compounds (PACs). These compounds have shown carcinogenic and/or mutagenic activity in laboratory experiments with animals. PACs are generally formed during incomplete combustion or pyrolysis of organic matter occurring in a variety of natural processes or human activities. Consequently, PAHs ar...
متن کامل